VDR Gene Haplotypes Associate with Type 1 Diabetes and Suggest Interaction with HLA, IL2RA and CTLA4 loci in Colombian Families
نویسندگان
چکیده
منابع مشابه
the past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
Association study of IL2RA and CTLA4 gene variants with type-1 diabetes mellitus in children in the northwest of Iran
Introduction Type 1 diabetes mellitus (T1D) (OMIM 222100) is an organ-specific and autoimmune disease that primarily affects children and adolescents. It is caused by destruction of the beta cells of Langerhans of the pancreas that secrete insulin, which occurs through the autoimmune processes. Therefore, the affected patients have to use insulin throughout their lives.1 The clinical symptoms o...
متن کاملHLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families.
OBJECTIVE The Type 1 Diabetes Genetics Consortium has collected type 1 diabetic families worldwide for genetic analysis. The major genetic determinants of type 1 diabetes are alleles at the HLA-DRB1 and DQB1 loci, with both susceptible and protective DR-DQ haplotypes present in all human populations. The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genoty...
متن کاملAssociation study of IL2RA and CTLA4 Gene Variants with Type I Diabetes Mellitus in children in the northwest of Iran
Introduction: A variety of genetic predisposing factors and environmental factors are known to influence the pathogenesis of type-1 diabetes (T1D). This study intended to investigate the association of cytotoxic T-lymphocyte associated protein 4 (CTLA4) and interleukin 2 receptor subunit alpha (IL2RA) gene polymorphisms with type 1 diabetes in children of northwest of Iran. Methods: Genomic DNA...
متن کاملstudy of dna interaction with ethylenediaminetetraacetic acid and sesamol food additives
برهمکنش dnaتیموس گاوی طبیعی (ct-dna) با اتیلن دی آمین تترااستات (edta)در بافرtris-hcl با 8/7 ph ( دراین ph،edta به نمک دی سدیم تبدیل می شود) وسسامول در بافر tris-hcl با4/7 ph مورد بررسی قرار گرفته است. edta و سسامول استفاده فراوانی در تکنولوژی غذایی و صنعت شیمیایی دارند. مدل اتصال dna مربوط بهedta بوسیله اسپکتروفتومتری جذب، دورنگ نمایی حلقوی(cd)، ویسکومتری وژل الکتروفورز بررسی شده است. طیفuv ...
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ژورنال
عنوان ژورنال: Current Research in Diabetes & Obesity Journal
سال: 2018
ISSN: 2476-1435
DOI: 10.19080/crdoj.2018.06.555688